Anticonvulsant Action of a New Analogue of Allopregnanolone in Immature Rats
نویسندگان
چکیده
منابع مشابه
Anticonvulsant action of a new analogue of allopregnanolone in immature rats.
Neuroactive steroids represent potential antiepileptic drugs. We tested a newly synthesized analogue of allopregnanolone 3alpha-hydroxy-21xi,22-oxido-21-homo-5alpha-pregnan-20-on (HOHP) against two types of pentylenetetrazol-induced seizures (100 mg/kg s.c.) in 12- and 25-day-old rats. Ganaxolone, a neuroactive steroid in clinical trials, served as a reference drug. Pretreatment with either ste...
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GABA exhibits depolarizing action in the immature neurons due to high intracellular activity of chloride ions. It is maintained by cation-chloride cotransporter NKCC1 which is present in immature brain. Bumetanide is a specific inhibitor of this cotransporter. We studied possible anticonvulsant activity of bumetanide in pentylenetetrazol-induced seizures in three age groups of rat pups (7, 12, ...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2010
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.931754